Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …
offer diagnostic information that is otherwise accessible conventionally through invasive …
[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management
AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
Toward the early detection of cancer by decoding the epigenetic and environmental fingerprints of cell-free DNA
Y Van Der Pol, F Mouliere - Cancer cell, 2019 - cell.com
Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …
Analytical and clinical validation of a digital sequencing panel for quantitative, highly accurate evaluation of cell-free circulating tumor DNA
RB Lanman, SA Mortimer, OA Zill, D Sebisanovic… - PloS one, 2015 - journals.plos.org
Next-generation sequencing of cell-free circulating solid tumor DNA addresses two
challenges in contemporary cancer care. First this method of massively parallel and deep …
challenges in contemporary cancer care. First this method of massively parallel and deep …
Enhanced detection of circulating tumor DNA by fragment size analysis
F Mouliere, D Chandrananda, AM Piskorz… - Science translational …, 2018 - science.org
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on
genomic alterations but have rarely considered the biological properties of plasma cell-free …
genomic alterations but have rarely considered the biological properties of plasma cell-free …
The nexus of cfDNA and nuclease biology
DSC Han, YMD Lo - Trends in Genetics, 2021 - cell.com
Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis
of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive …
of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive …
Inferring expressed genes by whole-genome sequencing of plasma DNA
P Ulz, GG Thallinger, M Auer, R Graf, K Kashofer… - Nature …, 2016 - nature.com
The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field in
medicine. cfDNA consists predominantly of nucleosome-protected DNA shed into the …
medicine. cfDNA consists predominantly of nucleosome-protected DNA shed into the …
Detection of therapeutically targetable driver and resistance mutations in lung cancer patients by next-generation sequencing of cell-free circulating tumor DNA
Purpose: The expanding number of targeted therapeutics for non–small cell lung cancer
(NSCLC) necessitates real-time tumor genotyping, yet tissue biopsies are difficult to perform …
(NSCLC) necessitates real-time tumor genotyping, yet tissue biopsies are difficult to perform …
The long and short of circulating cell-free DNA and the ins and outs of molecular diagnostics
P Jiang, YMD Lo - Trends in Genetics, 2016 - cell.com
The discovery of cell-free tumor and fetal DNA molecules in the plasma of cancer patients
and pregnant women, respectively, has opened up exciting opportunities in molecular …
and pregnant women, respectively, has opened up exciting opportunities in molecular …
The biology of cell-free DNA fragmentation and the roles of DNASE1, DNASE1L3, and DFFB
Cell-free DNA (cf. DNA) is a powerful noninvasive biomarker for cancer and prenatal testing,
and it circulates in plasma as short fragments. To elucidate the biology of cf. DNA …
and it circulates in plasma as short fragments. To elucidate the biology of cf. DNA …