The orphan nuclear receptors steroidogenic factor-1 and liver receptor homolog-1: structure, regulation, and essential roles in mammalian reproduction
MC Meinsohn, OE Smith, K Bertolin… - Physiological …, 2019 - journals.physiology.org
Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …
classic nuclear receptor domain structure lacking identified signaling ligands are designated …
Zygotic genome activation by the totipotency pioneer factor Nr5a2
Life begins with a switch in genetic control from the maternal to the embryonic genome
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …
Extra-adrenal glucocorticoid synthesis in the intestinal mucosa: between immune homeostasis and immune escape
A Ahmed, C Schmidt, T Brunner - Frontiers in immunology, 2019 - frontiersin.org
Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands
in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory …
in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory …
LRH‐1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
S Michalek, T Goj, AP Plazzo, B Marovca… - EMBO …, 2022 - embopress.org
Nuclear receptors are transcription factors with important functions in a variety of
physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity …
physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity …
[HTML][HTML] MicroRNA-219-5p represses the proliferation, migration, and invasion of gastric cancer cells by targeting the LRH-1/Wnt/β-catenin signaling pathway
C Li, J Dong, Z Han, K Zhang - Oncology research, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are reportedly involved in gastric cancer development and
progression. In particular, miR-219-5p has been reported to be a tumor-associated miRNA …
progression. In particular, miR-219-5p has been reported to be a tumor-associated miRNA …
LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner
HB Kramer, CF Lai, H Patel, M Periyasamy… - Nucleic acids …, 2016 - academic.oup.com
Abstract Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been
implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To …
implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To …
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1
MM Malabanan, P Chapagain, Z Haratipour… - ACS chemical …, 2023 - ACS Publications
Nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) is a lipid-regulated transcription
factor and an important drug target for several liver diseases. Advances toward LRH-1 …
factor and an important drug target for several liver diseases. Advances toward LRH-1 …
MicroRNA-374b reduces the proliferation and invasion of colon cancer cells by regulation of LRH-1/Wnt signaling
R Qu, S Hao, X Jin, G Shi, Q Yu, X Tong, D Guo - Gene, 2018 - Elsevier
Deregulation of microRNA (miRNA) has been suggested as a critical event in colon cancer
development and progression. Recent studies have suggested that miR-374b is a novel …
development and progression. Recent studies have suggested that miR-374b is a novel …
Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis
Abstract Liver receptor homolog-1 (LRH-1, Nr5a2) is an orphan nuclear receptor mainly
expressed in tissues of endodermal origin, where its physiological role has been extensively …
expressed in tissues of endodermal origin, where its physiological role has been extensively …
MicroRNA-381 suppresses cell growth and invasion by targeting the liver receptor homolog-1 in hepatocellular carcinoma
Q Zhang, S Zhao, X Pang, B Chi - Oncology reports, 2016 - spandidos-publications.com
MicroRNAs (miRs) have emerged as prospective tools for human cancer therapy, including
hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 …
hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 …