Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

In all organisms, innate immune pathways sense infection and rapidly activate potent
immune responses while avoiding inappropriate activation (autoimmunity). In humans, the …

Highlights•High potencies and prolonged effects achievable with covalent drugs may result
in less frequent dosing and improved therapeutic margins for patients.•Covalent inhibition …

NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

SUMOylation is a reversible post-translational modification that regulates protein function
through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of …

The post-translational modification of proteins regulates many biological processes. Their
dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications …

Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to
regulate such cellular processes as nuclear transport, transcription, chromosome …

Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …