The immunomodulatory and anti-inflammatory effect of curcumin on immune cell populations, cytokines, and in vivo models of rheumatoid arthritis

S Makuch, K Więcek, M Woźniak - Pharmaceuticals, 2021 - mdpi.com
Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints,
causing irreversible cartilage, synovium, and bone degradation. During the course of the …

Lactococcus lactis as an Interleukin Delivery System for Prophylaxis and Treatment of Inflammatory and Autoimmune Diseases

GM Campos, MF Américo, A dos Santos Freitas… - Probiotics and …, 2024 - Springer
Target delivery of therapeutic agents with anti-inflammatory properties using probiotics as
delivery and recombinant protein expression vehicles is a promising approach for the …

Identifying gene expression profiles associated with neurogenesis and inflammation in the human subependymal zone from development through aging

M Bitar, C Weissleder, HF North, MS Clearwater… - Scientific Reports, 2022 - nature.com
The generation of new neurons within the mammalian forebrain continues throughout life
within two main neurogenic niches, the subgranular zone (SGZ) of the hippocampal dentate …

Gene expression profiling in coeliac disease confirmed the key role of the immune system and revealed a molecular overlap with non-celiac gluten sensitivity

M Sallese, K Efthymakis, M Marchioni, B Neri… - International journal of …, 2023 - mdpi.com
Coeliac disease (CeD) is an immune-mediated disorder triggered by the ingestion of gluten
and an as yet unidentified environmental factor in genetically predisposed individuals. The …

Sirtuin 1, visfatin and IL-27 serum levels of type 1 diabetic females in relation to cardiovascular parameters and autoimmune thyroid disease

M Łukawska-Tatarczuk, E Franek, L Czupryniak… - Biomolecules, 2021 - mdpi.com
The loss of cardioprotection observed in premenopausal, diabetic women may result from
the interplay between epigenetic, metabolic, and immunological factors. The aim of this …

Changes in circulating cytokines and adipokines after RYGB in patients with and without type 2 diabetes

P Katsogiannos, PG Kamble, MJ Pereira, M Sundbom… - …, 2021 - Wiley Online Library
Objective This study aimed to compare cytokine and adipokine levels in patients with obesity
with and without type 2 diabetes (T2D) at baseline and 6 months after Roux‐en‐Y gastric …

Increased mutation rate and interlocus gene conversion within human segmental duplications

MR Vollger, WS DeWitt, PC Dishuck, WT Harvey… - bioRxiv, 2022 - biorxiv.org
Single-nucleotide variants (SNVs) within segmental duplications (SDs) have not been
systematically assessed because of the difficulty in mapping short-read sequence data to …

IL-27 Mediates Pro-Inflammatory Effects via the ERK Signaling Pathway During Preterm Labor

D Huang, Y Ran, Z Liu, J He, N Yin, H Qi - Frontiers in Immunology, 2021 - frontiersin.org
Preterm labor (PTL) is a multifactorial syndrome that results in birth prior to 37 weeks of
gestation. However, the specific molecular mechanisms underlying this condition have yet to …

Single-cell mass cytometry on peripheral cells in Myasthenia Gravis identifies dysregulation of innate immune cells

J Verdier, OM Fayet, E Hemery, F Truffault… - Frontiers in …, 2023 - frontiersin.org
Myasthenia Gravis (MG) is a neurological autoimmune disease characterized by disabling
muscle weaknesses due to anti-acetylcholine receptor (AChR) autoantibodies. To gain …

IL-27 protects the brain from ischemia-reperfusion injury via the gp130/STAT3 signaling pathway

C Luo, B Li, L Chen, L Zhao, Y Wei - Journal of Molecular Neuroscience, 2021 - Springer
The occurrence of ischemia-reperfusion (I/R) injury leads to dysfunction as well as high rates
of morbidity and mortality in stroke, and new effective therapeutic strategies for I/R are still …