Maternal low-grade chronic inflammation and intrauterine programming of health and disease

F Parisi, R Milazzo, VM Savasi, I Cetin - International journal of molecular …, 2021 - mdpi.com
Overweight and obesity during pregnancy have been associated with increased birth
weight, childhood obesity, and noncommunicable diseases in the offspring, leading to a …

Regulation of maternal–fetal metabolic communication

CE Bowman, Z Arany, MJ Wolfgang - Cellular and molecular life sciences, 2021 - Springer
Pregnancy may be the most nutritionally sensitive stage in the life cycle, and improved
metabolic health during gestation and early postnatal life can reduce the risk of chronic …

Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

EA Bordt, LL Shook, C Atyeo, KM Pullen… - Science translational …, 2021 - science.org
There is a persistent bias toward higher prevalence and increased severity of coronavirus
disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex …

Epigenetics and epigenomics: implications for diabetes and obesity

ED Rosen, KH Kaestner, R Natarajan, ME Patti… - Diabetes, 2018 - Am Diabetes Assoc
The American Diabetes Association convened a research symposium,“Epigenetics and
Epigenomics: Implications for Diabetes and Obesity” on 17–19 November 2017 …

Diet‐induced maternal obesity impacts feto‐placental growth and induces sex‐specific alterations in placental morphology, mitochondrial bioenergetics, dynamics …

T Napso, SC Lean, M Lu, EJ Mort… - Acta …, 2022 - Wiley Online Library
Aim The current study investigated the impact of maternal obesity on placental phenotype in
relation to fetal growth and sex. Methods Female C57BL6/J mice were fed either a diet high …

Effects of maternal obesity and gestational diabetes mellitus on the placenta: current knowledge and targets for therapeutic interventions

S Bedell, J Hutson, B de Vrijer… - Current vascular …, 2021 - ingentaconnect.com
Obesity and gestational diabetes mellitus (GDM) are becoming more common among
pregnant women worldwide and are individually associated with a number of placenta …

Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation

JG Wallace, CJ Bellissimo, E Yeo, Y Fei Xia, JJ Petrik… - Scientific reports, 2019 - nature.com
We investigated whether diet-induced changes in the maternal intestinal microbiota were
associated with changes in bacterial metabolites and their receptors, intestinal inflammation …

Maternal PUFAs, placental epigenetics, and their relevance to fetal growth and brain development

S Basak, AK Duttaroy - Reproductive Sciences, 2023 - Springer
Dietary polyunsaturated fatty acids (PUFAs), especially omega-3 (n-3) and n-6 long-chain
(LC) PUFAs, are indispensable for the fetus' brain supplied by the placenta. Despite being …

Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth

JS Son, X Liu, Q Tian, L Zhao, Y Chen… - The Journal of …, 2019 - Wiley Online Library
Key points Maternal exercise improves the metabolic health of maternal mice challenged
with a high‐fat diet. Exercise intervention of obese mothers prevents fetal overgrowth …

[HTML][HTML] Endothelial dysfunction in pregnancy metabolic disorders

C Echeverria, F Eltit, JF Santibanez, S Gatica… - … et Biophysica Acta (BBA …, 2020 - Elsevier
In recent years, the vascular endothelium has gained attention as a key player in the
initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ …