In this article we review recent advances in-value-based multiple test procedures (MTPs).
We begin with a brief review of the basic tests of Bonferroni and Simes. Standard stepwise …

There are various multiple comparison procedures used in confirmatory clinical studies and
exploratory research for multiplicity adjustment. Among them are the Hochberg and …

Closed testing procedures are classically used for familywise error rate control, but they can
also be used to obtain simultaneous confidence bounds for the false discovery proportion in …

Introduction Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its
homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive …

Falling in Parkinsonian syndromes (PS) is associated with postural instability and consists a
common cause of disability among PS patients. Current posturographic practices record the …

Studies of perceptual decision-making have often assumed that the main role of sensory
cortices is to provide sensory input to downstream processes that accumulate and drive …

Hommel's and Hochberg's procedures for familywise error control are both derived as
shortcuts in a closed testing procedure with the Simes local test. Hommel's shortcut is exact …

We consider a confirmatory clinical trial where a primary and a secondary endpoints are
tested hierarchically to control the family-wise error rate at level α. The trial uses a group …

Graphical approach provides a useful framework for multiplicity adjustment in clinical trials
with multiple endpoints. When designing a graphical approach, initial weight and transition …

For multiple comparisons in analysis of variance, the practitioners' handbooks generally
advocate standard methods such as Bonferroni, or an F-test followed by Tukey's honest …