Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Cholesterol stiffening of lipid membranes

FT Doole, T Kumarage, R Ashkar, MF Brown - The Journal of Membrane …, 2022 - Springer
Biomembrane order, dynamics, and other essential physicochemical parameters are
controlled by cholesterol, a major component of mammalian cell membranes. Although …

Controlled division of cell-sized vesicles by low densities of membrane-bound proteins

J Steinkühler, RL Knorr, Z Zhao, T Bhatia… - Nature …, 2020 - nature.com
The proliferation of life on earth is based on the ability of single cells to divide into two
daughter cells. During cell division, the plasma membrane undergoes a series of …

Physical properties of model biological lipid bilayers: insights from all-atom molecular dynamics simulations

G Shahane, W Ding, M Palaiokostas, M Orsi - Journal of molecular …, 2019 - Springer
The physical properties of lipid bilayers are sensitive to the specific type and composition of
the lipids that make up the many different types of cell membranes. Studying model bilayers …

A tuneable minimal cell membrane reveals that two lipid species suffice for life

I Justice, P Kiesel, N Safronova, A von Appen… - Nature …, 2024 - nature.com
All cells are encapsulated by a lipid membrane that facilitates their interactions with the
environment. How cells manage diverse mixtures of lipids, which dictate membrane property …

Role of lipid composition on the structural and mechanical features of axonal membranes: a molecular simulation study

M Saeedimasine, A Montanino, S Kleiven, A Villa - Scientific reports, 2019 - nature.com
The integrity of cellular membranes is critical for the functionality of axons. Failure of the
axonal membranes (plasma membrane and/or myelin sheath) can be the origin of …

Concepts and methods of solid-state NMR spectroscopy applied to biomembranes

TR Molugu, S Lee, MF Brown - Chemical reviews, 2017 - ACS Publications
Concepts of solid-state NMR spectroscopy and applications to fluid membranes are
reviewed in this paper. Membrane lipids with 2H-labeled acyl chains or polar head groups …

[HTML][HTML] Force field development for lipid membrane simulations

AP Lyubartsev, AL Rabinovich - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
With the rapid development of computer power and wide availability of modelling software
computer simulations of realistic models of lipid membranes, including their interactions with …

SARS-CoV-2 envelope protein forms clustered pentamers in lipid bilayers

NH Somberg, WW Wu, J Medeiros-Silva, AJ Dregni… - Biochemistry, 2022 - ACS Publications
The SARS-CoV-2 envelope (E) protein is a viroporin associated with the acute respiratory
symptoms of COVID-19. E forms cation-selective ion channels that assemble in the lipid …

Structure of POPC lipid bilayers in OPLS3e force field

M Kurki, A Poso, P Bartos… - Journal of Chemical …, 2022 - ACS Publications
It is crucial for molecular dynamics simulations of biomembranes that the force field
parameters give a realistic model of the membrane behavior. In this study, we examined the …