Purpose To provide an update about the rapidly developing changes in the critical care
management of acute ischaemic stroke patients. Methods A narrative review was conducted …

Ischemic stroke kills more women compared with men thus emphasizing a significant sexual
dimorphism in ischemic pathophysiological outcomes. However, the mechanisms behind …

Acute ischemic stroke is a leading cause of death and disability worldwide. Therapeutic
hypothermia has long been considered as one of the most robust neuroprotective strategies …

Therapeutic hypothermia has shown promise as a means to improving neurological
outcomes at several neurological conditions. At the clinical level, it has been shown to …

Blood–brain barrier (BBB) dysfunction and neuroinflammation are key mechanisms of brain
injury. We performed a time-course study following neonatal hypoxia–ischemia (HI) to …

Spreading depolarizations (SDs) have been linked to infarct volume expansion following
ischemic stroke. Therapeutic hypothermia provides a neuroprotective effect after ischemic …

Therapeutic hypothermia (TH) has applications dating back millennia. In modern history,
however, TH saw its importation into medical practice where investigations have …

“At a time of increasing challenges regarding the provision of a healthcare and concerns
around the use of antibiotics to manage infection, this book is timely addition to the field. The …

Ischemic injury leads to cell death and inflammatory responses after stroke. Microglia
especially play a crucial role in this brain inflammation. Targeted temperature management …

Currently, successful preclinical cerebroprotective agents fail to translate effectively into
clinical practice suggesting the need for a comprehensive evaluation of all aspects of brain …