The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Nature has developed a plethora of protein machinery to operate and maintain nearly every
task of cellular life. These processes are tightly regulated via post‐expression modifications …

Bispecific T cell engagers (BiTEs), a subset of bispecific antibodies (bsAbs), can promote a
targeted cancer cell's death by bringing it close to a cytotoxic T cell. Checkpoint inhibitory T …

The chemical synthesis of site‐specifically modified transcription factors (TFs) is a powerful
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …

Through mechanistic work and rational design, we have developed the fastest
organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au (III) …

Introduction In the field of bioconjugates, the focus on antibody–drug conjugates (ADCs)
with novel payloads beyond the traditional categories of potent cytotoxic agents is …

Chemical post-translational protein–protein conjugation is an important technique with
growing applications in biotechnology and pharmaceutical research. Maleimides represent …

Glycoengineering has provided powerful tools to construct site‐specific antibody conjugates.
However, only small‐molecule payloads can be directly transferred to native or engineered …

High molecular weight (MW), highly repetitive protein polymers are attractive candidates to
replace petroleum-derived materials as these protein-based materials (PBMs) are …

Bispecific antibodies as T cell engagers designed to display binding capabilities to both
tumor-associated antigens and antigens on T cells are considered promising agents in the …