Abstract Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-
stimulated signalling and in the regulation of membrane traffic. Several distinct classes of …

Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility
by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor …

The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during
G1 phase with the cell-cycle engine that regulates DNA replication and mitosis. Induction of …

The widely prevailing view that the cyclin‐dependent kinase inhibitors (CKIs) are solely
negative regulators of cyclin‐dependent kinases (CDKs) is challenged here by observations …

Insulin plays a key role in regulating a wide range of cellular processes. However, until
recently little was known about the signalling pathways that are involved in linking the …

Genetic aberrations in the regulatory circuits that govern transit through the G1 phase of the
cell cycle occur frequently in human cancer and overexpression of the G1 phase cyclin …

GSK-3β-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-
cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how …

Upon detachment from the extracellular matrix, epithelial cells enter into programmed cell
death, a phenomenon known as anoikis, ensuring that they are unable to survive in an …

Src family kinases (SFKs) have been implicated as important regulators of ligand‐induced
cellular responses including proliferation, survival, adhesion and migration. Analysis of SFK …

The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …