Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor
(EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF …

Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end‐stage renal disease. Although many studies have …

Despite the increasingly important role of Hippo-Yap in hepatocellular carcinoma (HCC)
development and progression, little insight is available at the time regarding the specifics …

The Src kinase controls aspects of cell biology and its activity is regulated by intramolecular
structural changes induced by protein interactions and tyrosine phosphorylation. Recent …

Colorectal cancer (CRC) is prevalent worldwide. Dietary consumption of procyanidins has
been linked to a reduced risk of developing CRC. The epidermal growth factor (EGF) …

Background The epidermal growth factor receptor (EGFR) plays important roles in cell
survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common …

Epidermal growth factor receptor (EGFR) is a target of signal-derived H 2 O 2, and oxidation
of active-site cysteine 797 to sulfenic acid enhances kinase activity. Although a major class …

Photodynamic therapy (PDT) is a potential synergistic approach to chemotherapy for treating
ovarian cancer, the most lethal gynecologic malignancy. Here we used M13 bacteriophage …

Membranes are of outmost importance to allow for specific signal transduction due to their
ability to localize, amplify, and direct signals. However, due to the double-edged nature of …

Despite extensive research on molecular pathways controlling the process of regeneration
in model organisms, little is known about the actual initiation signals necessary to induce …