Miniscope-LFOV: a large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals

C Guo, GJ Blair, M Sehgal, FN Sangiuliano Jimka… - Science …, 2023 - science.org
Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger
than mice remains a key endeavor of neuroscience. We present a large-field-of-view open …

Advances of optical miniscopes for in vivo imaging of neural activity in freely moving animals

K Chen, Z Tian, L Kong - Frontiers in Neuroscience, 2022 - frontiersin.org
To study neural mechanisms of ethologically relevant behaviors including many social
behaviors and navigations, optical miniscopes, which can be carried by the model animals …

Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope

J Wu, Y Chen, A Veeraraghavan, E Seidemann… - Nature …, 2024 - nature.com
Mesoscopic calcium imaging enables studies of cell-type specific neural activity over large
areas. A growing body of literature suggests that neural activity can be different when …

Large depth-of-field ultra-compact microscope by progressive optimization and deep learning

Y Zhang, X Song, J Xie, J Hu, J Chen, X Li… - Nature …, 2023 - nature.com
The optical microscope is customarily an instrument of substantial size and expense but
limited performance. Here we report an integrated microscope that achieves optical …

Three-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation

Q Zhou, Z Chen, YH Liu, M El Amki, C Glück… - Nature …, 2022 - nature.com
Wide-field fluorescence imaging is an indispensable tool for studying large-scale
biodynamics. Limited space-bandwidth product and strong light diffusion make conventional …

New imaging instrument in animal models: Two‐photon miniature microscope and large field of view miniature microscope for freely behaving animals

C Guo, A Wang, H Cheng, L Chen - Journal of Neurochemistry, 2023 - Wiley Online Library
Over the past decade, novel optical imaging tools have been developed for imaging
neuronal activities along with the evolution of fluorescence indicators with brighter …

A miniature fluorescence microscope for multi-plane imaging

G Barbera, R Jun, Y Zhang, B Liang, Y Li, DT Lin - Scientific Reports, 2022 - nature.com
Miniature fluorescence microscopes are becoming an increasingly established tool to
investigate neural circuits in freely moving animals. In this work we present a lightweight one …

Trans-segmental imaging in the spinal cord of behaving mice

P Shekhtmeyster, D Duarte, EM Carey, A Ngo… - Nature …, 2023 - nature.com
Spinal cord circuits play crucial roles in transmitting pain, but the underlying activity patterns
within and across spinal segments in behaving mice have remained elusive. We developed …

A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice

Y Zhang, L Yuan, Q Zhu, J Wu, T Nöbauer… - Nature Biomedical …, 2024 - nature.com
Exploring the relationship between neuronal dynamics and ethologically relevant behaviour
involves recording neuronal-population activity using technologies that are compatible with …

A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Y Zhang, L Yuan, J Wu, T Noebauer, R Zhang, G Xiao… - bioRxiv, 2024 - biorxiv.org
Understanding how neuronal dynamics gives rise to ethologically relevant behavior requires
recording of neuronal population activity via technologies that are compatible with …