Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

RHB Benedict, MP Amato, J DeLuca… - The Lancet …, 2020 - thelancet.com
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Secondary progressive multiple sclerosis: new insights

BAC Cree, DL Arnold, J Chataway, T Chitnis, RJ Fox… - Neurology, 2021 - AAN Enterprises
In most cases, multiple sclerosis (MS) begins with a relapsing-remitting course followed by
insidious disability worsening that is independent from clinically apparent relapses and is …

A quarter century of APOE and Alzheimer's disease: progress to date and the path forward

ME Belloy, V Napolioni, MD Greicius - Neuron, 2019 - cell.com
Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Multiple neuroinvasive pathways in COVID-19

D Bougakov, K Podell, E Goldberg - Molecular neurobiology, 2021 - Springer
COVID-19 is a highly infectious viral disease caused by the novel coronavirus SARS-CoV-2.
While it was initially regarded as a strictly respiratory illness, the impact of COVID-19 on …

Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study

AJC Eijlers, Q van Geest, I Dekker, MD Steenwijk… - Brain, 2018 - academic.oup.com
Cognitive decline is common in multiple sclerosis and strongly affects overall quality of life.
Despite the identification of cross-sectional MRI correlates of cognitive impairment …

Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational Psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Symbol digit modalities test: a valid clinical trial endpoint for measuring cognition in multiple sclerosis

L Strober, J DeLuca, RHB Benedict… - Multiple Sclerosis …, 2019 - journals.sagepub.com
Background: The need for more robust outcomes in multiple sclerosis (MS) clinical trials has
been a main priority of the field for decades. Dissatisfaction with existing measures has led …

Comprehensive approach to management of multiple sclerosis: addressing invisible symptoms—a narrative review

L Lakin, BE Davis, CC Binns, KM Currie… - Neurology and therapy, 2021 - Springer
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous
system, leading to neurodegeneration and manifesting as a variety of symptoms. These can …

Digital biomarkers in multiple sclerosis

A Dillenseger, ML Weidemann, K Trentzsch, H Inojosa… - Brain sciences, 2021 - mdpi.com
For incurable diseases, such as multiple sclerosis (MS), the prevention of progression and
the preservation of quality of life play a crucial role over the entire therapy period. In MS …