Substitution of NH3 by a range of amines in trans‐[PtCl2 (NH3) 2] produces compounds with
cytotoxicity significantly improved over the parent transplatin and in many cases equivalent …

Cisplatin plays a central role in cancer chemotherapy in spite of its toxicity. To circumvent
this toxicity and to enhance its therapeutic index a lot of preclinical and clinical studies have …

We characterized the pro-apoptotic activity of two new synthesized isatin-Schiff base copper
(II) complexes, obtained from isatin and 1, 3-diaminopropane or 2-(2-aminoethyl) …

The ideal drug discovery process of new platinum based drugs should take into account
three basic fundaments: on one side the mechanisms of action and the corresponding target …

Since the introduction of cisplatin to oncology in 1978, Pt (II) and Pd (II) compounds have
been intensively studied with a view to develop the improved anticancer agents. Polynuclear …

In this paper we summarize the work on the development of trans-platinum complexes as
antitumor agents during the last 15 years. We review the structures and chemical properties …

A meso-p-nitroaniline-calix [4] pyrrole derivative trans-coordinated to a Pt (II) center was
synthesized and its structure solved by X-ray analysis. Adenosine monophosphate (AMP) …

It is a therapeutic strategy for cancers including pancreatic to inhibit proteasome activity.
Disulfiram (DSF) may bind copper (Cu) to form a DSF–Cu complex. DSF–Cu is capable of …

Platinum drugs are widely used in antitumour therapy and are a cornerstone of the treatment
of different solid tumours. The pharmacological interest of cisplatin has led to the design of …

Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated
antitumor activity in vitro and in vivo against a variety of cell and tumor types. The …