Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

The role of miRNAs in liver diseases: Potential therapeutic and clinical applications

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
MicroRNAs (miRNAs) are a class of short, non-coding RNAs that function post-
transcriptionally to regulate gene expression by binding to particular mRNA targets and …

Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

The role of exosomes and exosomal microRNA in cardiovascular disease

D Zheng, M Huo, B Li, W Wang, H Piao… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane
bilayer, secreted by most cells in the body. They carry various molecules, including proteins …

Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment

SR Botts, JE Fish, KL Howe - Frontiers in pharmacology, 2021 - frontiersin.org
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

BMSC-derived exosomal miR-29a promotes angiogenesis and osteogenesis

G Lu, P Cheng, T Liu, Z Wang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Angiogenesis and osteogenesis are tightly coupled during bone modeling and remodeling
processes. Here we reported that bone marrow mesenchymal stem cell (BMSC)-derived …

Cellular crosstalk between endothelial and smooth muscle cells in vascular wall remodeling

N Méndez-Barbero, C Gutiérrez-Muñoz… - International journal of …, 2021 - mdpi.com
Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …

M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment

S Liu, J Chen, J Shi, W Zhou, L Wang, W Fang… - Basic research in …, 2020 - Springer
The roles and the underlying mechanisms of M1-type macrophages in angiogenesis and
postmyocardial infarction (MI) cardiac repair have remained unclear. In this study, we …

Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis

B Yue, H Yang, J Wang, W Ru, J Wu, Y Huang… - Cell …, 2020 - Wiley Online Library
Exosomes are membrane‐bound extracellular vesicles that are produced in the endosomal
compartment of most mammalian cell types and then released. Exosomes are effective …

miR-98 regulates TMPRSS2 expression in human endothelial cells: key implications for COVID-19

A Matarese, J Gambardella, C Sardu, G Santulli - Biomedicines, 2020 - mdpi.com
The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and …