Antibody glycosylation and its impact on the pharmacokinetics and pharmacodynamics of monoclonal antibodies and Fc-fusion proteins

L Liu - Journal of pharmaceutical sciences, 2015 - Elsevier
Understanding the impact of glycosylation and keeping a close control on glycosylation of
product candidates are required for both novel and biosimilar monoclonal antibodies (mAbs) …

Host control of fungal infections: lessons from basic studies and human cohorts

MS Lionakis, SM Levitz - Annual review of immunology, 2018 - annualreviews.org
In the last few decades, the AIDS pandemic and the significant advances in the medical
management of individuals with neoplastic and inflammatory conditions have resulted in a …

[HTML][HTML] Exploitation of the macrophage mannose receptor (CD206) in infectious disease diagnostics and therapeutics

AK Azad, MVS Rajaram… - Journal of cytology & …, 2014 - ncbi.nlm.nih.gov
The macrophage mannose receptor (MR, CD206) is a C-type lectin expressed
predominantly by most tissue macrophages, dendritic cells and specific lymphatic or …

Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations

S Boune, P Hu, AL Epstein, LA Khawli - Antibodies, 2020 - mdpi.com
The development of recombinant therapeutic proteins has been a major revolution in
modern medicine. Therapeutic-based monoclonal antibodies (mAbs) are growing rapidly …

Targeting C-type lectin receptors with multivalent carbohydrate ligands

B Lepenies, J Lee, S Sonkaria - Advanced drug delivery reviews, 2013 - Elsevier
C-type lectin receptors (CLRs) represent a large receptor family including collectins,
selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous …

Targeting antigens to dendritic cell receptors for vaccine development

V Apostolopoulos, T Thalhammer… - Journal of drug …, 2013 - Wiley Online Library
Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system
which play a key role in regulating immune responses. Depending on the method of antigen …

Dendritic cell interaction with Candida albicans critically depends on N-linked mannan

A Cambi, MG Netea, HM Mora-Montes… - Journal of Biological …, 2008 - ASBMB
The fungus Candida albicans is the most common cause of mycotic infections in
immunocompromised hosts. Little is known about the initial interactions between Candida …

[HTML][HTML] An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen

M Limonta-Fernández, G Chinea-Santiago… - New …, 2022 - Elsevier
Developing affordable and easily manufactured SARS-CoV-2 vaccines will be essential to
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …

Advances in combating fungal diseases: vaccines on the threshold

JE Cutler, GS Deepe Jr, BS Klein - Nature Reviews Microbiology, 2007 - nature.com
The dramatic increase in fungal diseases in recent years can be attributed to the increased
aggressiveness of medical therapy and other human activities. Immunosuppressed patients …

Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate

WH Chen, J Wei, RT Kundu, R Adhikari, Z Liu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has
now spread worldwide to infect over 110 million people, with approximately 2.5 million …