HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of …

Analysis of HIV drug resistance has identified sites on HIV target genes that convey
resistance to particular classes of agents. These data may be especially important in …

The HIV-1 integrase, responsible for the chromosomal integration of the newly synthesized
doublestranded viral DNA into the host genomic DNA, represents a new and important …

The picture of HIV-1 genetic diversity in the global pandemic continues to evolve.
Identification of new variants, including circulating and unique recombinant forms …

Most of the current knowledge on antiretroviral (ARV) drug development and resistance is
based on the study of subtype B of HIV-1, which only accounts for 10% of the worldwide HIV …

Combined HIV antiretroviral therapy (cART) has been effective except if drug resistance
emerges. As cART has been rolled out in low-income countries, drug resistance has …

The vast majority of reports on drug resistance deal with subtype B infections in developed
countries, and this is largely due to historical delays in access to antiretroviral therapy (ART) …

Objectives: To describe the molecular and epidemiological profile of HIV-1 in patients
followed at the University Hospital of Rio Grande, Brazil. Design and methods: A cross …

Recombination is an important way to generate genetic diversity. Accumulation of HIV-1 full-
length genomes in databases demonstrated that recombination is pervasive in viral strains …

Objective: To investigate the origin and to reconstruct the onset date of the HIV-1 subtype C
epidemic in Brazil. Design: Three independent datasets of subtype C sequences isolated …