[HTML][HTML] G protein-coupled receptor dimerisation: molecular basis and relevance to function

G Milligan - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2007 - Elsevier
The belief that G protein-coupled receptors exist and function as monomeric, non-interacting
species has been largely supplanted in recent years by evidence, derived from a range of …

Methods used to study the oligomeric structure of G-protein-coupled receptors

H Guo, S An, R Ward, Y Yang, Y Liu, XX Guo… - Bioscience …, 2017 - portlandpress.com
G-protein-coupled receptors (GPCRs), which constitute the largest family of cell surface
receptors, were originally thought to function as monomers, but are now recognized as …

[HTML][HTML] Hetero-dimerization of serotonin 5-HT2A and dopamine D2 receptors

S Łukasiewicz, A Polit, S Kędracka-Krok… - … et Biophysica Acta (BBA …, 2010 - Elsevier
In the present study, detailed information is presented on the hetero-dimerization of the
serotonin 5-HT2A receptor and the dopamine D2 receptor. Biophysical approaches …

Computational modeling approaches to structure− function analysis of G protein-coupled receptors

F Fanelli, PG De Benedetti - Chemical reviews, 2005 - ACS Publications
Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1-3 G …

Disruption of rhodopsin dimerization with synthetic peptides targeting an interaction interface

B Jastrzebska, Y Chen, T Orban, H Jin… - Journal of Biological …, 2015 - ASBMB
Although homo-and heterodimerizations of G protein-coupled receptors (GPCRs) are well
documented, GPCR monomers are able to assemble in different ways, thus causing …

A day in the life of a G protein‐coupled receptor: the contribution to function of G protein‐coupled receptor dimerization

G Milligan - British journal of pharmacology, 2008 - Wiley Online Library
G protein‐coupled receptors are one of the most actively studied families of proteins.
However, despite the ubiquity of protein dimerization and oligomerization as a structural and …

Serotonin 2A (5-HT2A) receptor function: ligand-dependent mechanisms and pathways

I Raote, A Bhattacharya… - Serotonin receptors in …, 2007 - books.google.com
G-protein-coupled receptors or GPCRs have been a major area of study in the past
decades. This is not surprising as this group, comprising a thousand-odd proteins …

[PDF][PDF] Update 1 of: computational modeling approaches to structure–function analysis of G protein-coupled receptors

F Fanelli, PG De Benedetti - Chemical Reviews-Columbus, 2011 - researchgate.net
Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication

D Guidolin, M Marcoli, C Tortorella, G Maura… - Reviews in the …, 2018 - degruyter.com
The proposal of receptor-receptor interactions (RRIs) in the early 1980s broadened the view
on the role of G protein-coupled receptors (GPCR) in the dynamics of the intercellular …

G-protein-coupled receptor type A heteromers as an emerging therapeutic target

D Guidolin, LF Agnati, M Marcoli… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: The discovery of receptor–receptor interactions (RRIs) in the early 1980s
provided evidence that G-protein-coupled receptors (GPCRs) operate not only as monomers …