The skin barrier function has been attributed to the stratum corneum and represents a major
challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a …

For glioblastoma, the tumor microenvironment (TME) is pivotal to support tumor progression
and therapeutic resistance. TME consists of several types of stromal, endothelial and …

The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …

In traumatic brain injury (TBI) patients, elevation of the brain extracellular lactate
concentration and the lactate/pyruvate ratio are well-recognized, and are associated …

Microdialysis has contributed with very important knowledge to the understanding of target-
specific concentrations and their relationship to pharmacodynamic effects from a systems …

Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are major contributors to
morbidity and mortality. Following the initial insult, patients may deteriorate due to secondary …

BACKGROUND Due to difficulty in accessing relevant tissues or biological fluids to measure
drug levels, plasma drug concentrations are often collected with the hope that they will …

Functional synapses in the central nervous system depend on a chemical signal exchange
process that involves neurotransmitter delivery between neurons and receptor cells in the …

Traumatic brain injury (TBI) is the commonest cause of death and disability in those aged
under 40 years. Interleukin-1 receptor antagonist (IL1ra) is an endogenous competitive …

Microdialysis is a powerful sampling technique that enables monitoring of dynamic
processes in vitro and in vivo. The combination of microdialysis with chromatographic or …