Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals

L Zhang, C Virgous, H Si - The Journal of nutritional biochemistry, 2019 - Elsevier
The anti-inflammatory effects of phytochemicals, bioactive components from plants having
health benefits, have been heavily investigated in the last several decades. However, the …

Targeting extracellular matrix through phytochemicals: a promising approach of multi-step actions on the treatment and prevention of cancer

D Liang, L Liu, Y Zhao, Z Luo, Y He, Y Li… - Frontiers in …, 2023 - frontiersin.org
Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor
microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell …

[HTML][HTML] Investigation of the anti-inflammatory and analgesic activities of promising pyrazole derivative

AA Bekhit, SN Nasralla, EJ El-Agroudy… - European Journal of …, 2022 - Elsevier
The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as
well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to …

The potency of heterocyclic curcumin analogues: An evidence-based review

FC Rodrigues, NVA Kumar, G Thakur - Pharmacological Research, 2021 - Elsevier
Curcumin, a potent phytochemical, has been a significant lead compound and has been
extensively investigated for its multiple bioactivities. Owing to its natural origin, non-toxic …

[HTML][HTML] Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer

X Zhou, X Wang, Q Sun, W Zhang, C Liu, W Ma… - Biomedicine & …, 2022 - Elsevier
With the development in tumor immunology, people are gradually understanding the
complexity and diversity of the tumor microenvironment immune status and its important …

Screening of In-Vitro Anti-Inflammatory and Antioxidant Activity of Sargassum ilicifolium Crude Lipid Extracts from Different Coastal Areas in Indonesia

Saraswati, PE Giriwono, D Iskandriati, N Andarwulan - Marine Drugs, 2021 - mdpi.com
Sargassum brown seaweed is reported to exhibit several biological activities which promote
human health, such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, and …

Histone deacetylase 2 is essential for LPS‐induced inflammatory responses in macrophages

C Wu, A Li, J Hu, J Kang - Immunology and cell biology, 2019 - Wiley Online Library
The role of specific histone deacetylase (HDAC) proteins in regulating the
lipopolysaccharide (LPS)‐induced inflammatory response and its underlying mechanisms …

Recent updates in curcumin pyrazole and isoxazole derivatives: synthesis and biological application

S Mishra, S Patel, CG Halpani - Chemistry & biodiversity, 2019 - Wiley Online Library
Curcumin is an admired, plant‐derived compound that has been extensively investigated for
diverse range of biological activities, but the use of this polyphenol is limited due to its …

The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer

WAN Liang-Qin, TAN Yan, M Jiang… - Chinese Journal of Natural …, 2019 - Elsevier
Non-small cell lung cancer (NSCLC) accounts for 80%–85% of all lung malignancies and
good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate …

Polymeric scaffold integrated with nanovesicle-entrapped curcuminoids for enhanced therapeutic efficacy

S Singh, N Supaweera, OF Nwabor, G Yusakul… - …, 2024 - Taylor & Francis
Aim: Polymeric scaffolds were developed fortified with nanovesicle-encapsulated individual
curcumin (CUR) and tetrahydrocurcumin (THC) for improved therapeutic efficacy due to their …