Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and
overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the …

Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

For over seven decades, bacteria served as a valuable source of bioactive natural products
some of which were eventually developed into drugs to treat infections, cancer and immune …

Marine actinomycetes are prolific sources of marine drug discovery system contributing for
several bioactive compounds of biomedical prominence. Metagenomics, a culture …

Actinomycetes are the main sources of antibiotics. The onset and level of production of each
antibiotic is subject to complex control by multi-level regulators. These regulators exert their …

Background Genome sequencing revealed that Streptomyces sp. can dedicate up to~ 10%
of their genomes for the biosynthesis of bioactive secondary metabolites. However, the …

Actinobacteria are among the most prolific sources of medically and agriculturally important
compounds, derived from their biosynthetic gene clusters (BGCs) for specialized …

Abstract Cyclic dimeric 3′-5′ guanosine monophosphate, c-di-GMP, is a ubiquitous
second messenger controlling diverse cellular processes in bacteria. In streptomycetes, c-di …

Streptomyces species are soil-dwelling bacteria that produce vast numbers of
pharmaceutically valuable secondary metabolites (SMs), such as antibiotics …