Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …

Topoisomerases are essential enzymes solving DNA topological problems such as
supercoils, knots and catenanes that arise from replication, transcription, chromatin …

The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …

In response to DNA damage, cells have developed a sophisticated signaling pathway,
consisting of DNA damage sensors, transducers, and effectors, to ensure efficient and …

Background Homozygous deletion of methylthioadenosine phosphorylase (MTAP) occurs
in∼ 10%-15% of solid tumors. AMG 193, a CNS-penetrant methylthioadenosine …

Radioresistance is regarded as the main cause of local recurrence and distant metastasis in
non-small cell lung cancer. However, the underlying mechanisms of radioresistance …

Abstract Protein arginine methyltransferase 5 (PRMT5) was discovered two decades ago.
The first decade focused on the biochemical characterization of PRMT5 as a regulator of …