This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The human ether-à-go-go-related potassium channel (hERG, Kv11. 1) is a voltage-
dependent channel known for its role in repolarizing the cardiac action potential. hERG …

Drug metabolism can produce metabolites with physicochemical and pharmacological
properties that differ substantially from those of the parent drug, and consequently has …

The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …

Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of
malignancies. Cardiotoxicity is a well‑recognized side effect of anthracycline therapy that …

Potassium channels are transmembrane proteins that selectively facilitate the flow of
potassium ions down an electrochemical gradient. These molecules have been studied in …

Cardiovascular diseases are a leading cause of morbidity and mortality in most developed
countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to …

The therapeutic success of human stem cell-derived cardiomyocytes critically depends on
their ability to respond to and integrate with the surrounding electromechanical environment …