Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in
particular, is challenging as the peripheral and central pain mechanisms are not fully …

Background: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical
applications. However, clinical outcome studies have not consistently shown positive effects …

Background Expanded distribution of pain is considered a sign of central sensitization (CS).
The relationship between recording of symptoms and CS in people with knee osteoarthritis …

Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly
than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in …

Objective Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses
than men. However, the underlying factors and therapeutic outcomes of these sex-specific …

Objective This review outlines the most commonly used quantitative sensory tests to identify
pain sensitization. We examine cross–sectional associations between quantitative sensory …

Growing evidence suggests that chronic low back pain (CLBP) is associated with pain
sensitization, and that there are sex and race disparities in CLBP. Given the sex and race …

Background: Despite growing awareness of the contribution of central pain mechanisms to
knee osteoarthritis pain in a subgroup of patients, routine evaluation of central sensitization …

Inhibitors of the cyclooxygenases (COXs), the nonsteroidal antiinflammatory drugs
(NSAIDs), relieve inflammatory pain, but are associated with gastrointestinal and …