Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

The molecular bases of training adaptation

VG Coffey, JA Hawley - Sports medicine, 2007 - Springer
Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in
response to disruptions to cellular homeostasis. The process of exerciseinduced adaptation …

Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment

MS Fragala, AM Kenny, GA Kuchel - Sports medicine, 2015 - Springer
Aging is often accompanied by declines in physical functioning which impedes older adults'
quality of life, sense of independence, and ability to perform daily tasks. Age-related …

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

AAW Cramer, V Prasad, E Eftestøl, T Song… - Nature …, 2020 - nature.com
Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially …

The muscle fiber type–fiber size paradox: hypertrophy or oxidative metabolism?

T Van Wessel, A De Haan, WJ Van Der Laarse… - European journal of …, 2010 - Springer
An inverse relationship exists between striated muscle fiber size and its oxidative capacity.
This relationship implies that muscle fibers, which are triggered to simultaneously increase …

Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways

NE Brooks, KH Myburgh - Frontiers in physiology, 2014 - frontiersin.org
Maintenance of skeletal muscle is essential for health and survival. There are marked losses
of skeletal muscle mass as well as strength and physiological function under conditions of …

Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

KA Murach, CS Fry, TJ Kirby, JR Jackson… - …, 2018 - journals.physiology.org
Recent loss-of-function studies show that satellite cell depletion does not promote
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …

Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and detraining in adult mice

KA Murach, CB Mobley, CJ Zdunek… - Journal of cachexia …, 2020 - Wiley Online Library
Background In the context of mass regulation,'muscle memory'can be defined as long‐
lasting cellular adaptations to hypertrophic exercise training that persist during detraining …

Number and spatial distribution of nuclei in the muscle fibres of normal mice studied in vivo

JC Bruusgaard, K Liestøl, M Ekmark… - The Journal of …, 2003 - Wiley Online Library
We present here a new technique with which to visualize nuclei in living muscle fibres in the
intact animal, involving injection of labelled DNA into single cells. This approach allowed us …

Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and sub-Sahara African populations in Europe and their countries of origin: an overview

IM Van der Meer, BJC Middelkoop, AJP Boeke… - Osteoporosis …, 2011 - Springer
Vitamin D status of nonwestern immigrants in Europe was poor. Vitamin D status of
nonwestern populations in their countries of origin varied, being either similar to the …