The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

BAH Smith, CR Bertozzi - Nature reviews Drug discovery, 2021 - nature.com
Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

[HTML][HTML] P‐and E‐selectin in venous thrombosis and non‐venous pathologies

M Purdy, A Obi, D Myers, T Wakefield - Journal of Thrombosis and …, 2022 - Elsevier
Venous thromboembolism is a very common and costly health problem worldwide.
Anticoagulant treatment for VTE is imperfect: all have the potential for significant bleeding …

Contemporary and Evidence-Based Medical Therapy for VTE

OY Moreno-Rocha, AT Obi, TW Wakefield - … Management of Acute and … - taylorfrancis.com
Venous thrombosis is a unique vascular pathology affecting the venous circulation and can
cause local and systemic consequences of primary thrombus and subsequent emboli.(1) It is …

[图书][B] Discovery and Characterization of Glyco-Immune Checkpoints

BAH Smith - 2021 - search.proquest.com
Glycans are complex polysaccharides that decorate the surface of every cell in the human
body and have functions spanning many essential aspects of cell and organismal biology …