Global regulatory reforms to promote equitable vaccine access in the next pandemic
There is broad consensus that the global response to the Covid-19 pandemic was
inadequate, leading to unacceptable levels of avoidable morbidity and mortality. Three …
inadequate, leading to unacceptable levels of avoidable morbidity and mortality. Three …
The zebrafish as a potential model for vaccine and adjuvant development
PJ Hotez, ME Bottazzi, NY Islam, J Lee… - Expert Review of …, 2024 - Taylor & Francis
Introduction Zebrafishes represent a proven model for human diseases and systems
biology, exhibiting physiological and genetic similarities and having innate and adaptive …
biology, exhibiting physiological and genetic similarities and having innate and adaptive …
A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses
SR Thimmiraju, R Adhikari, JAR Redd, MJ Villar, J Lee… - npj Vaccines, 2024 - nature.com
The development of broad-spectrum coronavirus vaccines is essential to prepare for future
respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit …
respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit …
A recombinant protein XBB. 1.5 RBD/Alum/CpG vaccine elicits high neutralizing antibody titers against omicron subvariants of SARS-CoV-2
SR Thimmiraju, R Adhikari, MJ Villar, J Lee, Z Liu… - Vaccines, 2023 - mdpi.com
(1) Background: We previously reported the development of a recombinant protein SARS-
CoV-2 vaccine, consisting of the receptor-binding domain (RBD) of the SARS-CoV-2 spike …
CoV-2 vaccine, consisting of the receptor-binding domain (RBD) of the SARS-CoV-2 spike …
Global Vaccine Access Demands Combating Both Inequity And Hesitancy: Commentary reflects on the COVID-19 pandemic vaccine experience and the need to …
PJ Hotez - Health Affairs, 2023 - healthaffairs.org
The world's population suffered from lack of access to COVID-19 vaccines. Although
inequities in vaccine availability for low-and middle-income countries are widely cited as a …
inequities in vaccine availability for low-and middle-income countries are widely cited as a …
A Journey in Science: Molecular vaccines for global child health in troubled times of anti-science
PJ Hotez - Molecular Medicine, 2024 - Springer
My scientific life in translational medicine runs in two parallel, yet often converging paths.
The first, is four-decade-long commitment to develop new vaccines for parasitic and …
The first, is four-decade-long commitment to develop new vaccines for parasitic and …
Scalable bioprocess for high-yield production of SARS-CoV-2 trimeric spike protein-based immunogen (IMT-CVAX) using suspension CHO cells
The COVID-19 pandemic has brought global attention towards the readiness of
biotechnology platforms for rapid development of immunogens to be used as vaccine …
biotechnology platforms for rapid development of immunogens to be used as vaccine …
[HTML][HTML] Immunogenicity and Safety of SARS-CoV-2 Protein Subunit Recombinant Vaccine (IndoVac®) as a Heterologous Booster Dose against COVID-19 in …
Adolescents are vulnerable to Coronavirus disease 2019 (COVID-19) infections; thus, their
antibodies should be maintained above the protective value. This study aimed to evaluate …
antibodies should be maintained above the protective value. This study aimed to evaluate …
Choice of adjuvant and antigen composition alters the immunogenic profile of a SARS-CoV-2 subunit vaccine
Introduction: Since their introduction, adjuvanted recombinant subunit vaccines against
COVID-19 have played a pivotal role in protecting global populations. Optimizing the …
COVID-19 have played a pivotal role in protecting global populations. Optimizing the …
Immunogenicity and Safety of SARS-CoV-2 Protein Subunit Recombinant Vaccine (IndoVac®) as a Booster Dose against COVID-19 in Indonesian Adults
According to the WHO target product profile for COVID-19 vaccines, the vaccine in
development should be indicated for active immunisation in all populations. Therefore, PT …
development should be indicated for active immunisation in all populations. Therefore, PT …