Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Human diseases are often caused by loss of somatic cells that are incapable of re-entering
the cell cycle for regenerative repair. Here, we report a combination of cell-cycle regulators …

Cloning of multiple genes in a single vector has greatly facilitated both basic and
translational studies that require co-expression of multiple factors or multi-units of complex …

Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …

Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …