Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Cationic lipids have become known as one of the most versatile tools for the delivery of
DNA, RNA and many other therapeutic molecules, and are especially attractive because …

Abstract Initially, the Atherton–Todd (AT) reaction was applied for the synthesis of
phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of …

Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …

Synthetic vectors for therapeutic nucleic acid delivery are currently competing significantly
with their viral counter parts due to their reduced immunogenicity, large payload capacity …

For cystic fibrosis gene therapy, the aerosolization of genetic materials is the most relevant
delivery strategy to reach the airway epithelium. However, aerosolized formulations have to …

Diseases that are linked to defective genes or mutations can in principle be cured by gene
therapy, in which damaged or absent genes are either repaired or replaced by new DNA in …

The study presents the effects of blending a cationic gemini surfactant into cationic lipid
bilayers and its impact on the plasmid DNA compaction and delivery process. Using …

Twelve new quaternary ammonium sophorolipids with long alkyl chains on the nitrogen
atom were synthesized starting from oleic and petroselinic acid‐based sophorolipids. These …

Herein, five new α-tocopheryl cationic gemini lipids with hydroxyethyl bearing headgroups
(THnS, n= 4, 5, 6, 8, 12) have been synthesized for efficient plasmid DNA (pDNA) delivery …