Accumulating evidence shows that deregulation of fatty acid (FA) metabolism is associated
with the development of cancer. Long-chain acyl-coenzyme A synthases (ACSLs) are …

Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …

Reprogramming of lipid metabolism, which modulates energy utilization and cell signaling,
maintains cell survival and promotes cancer metastasis in cancer cells. Ferroptosis is a type …

In mammalian cells, tyrosine phosphorylation is one of the main mechanisms responsible for
regulating signal transduction pathways and key cellular functions. Moreover, recent studies …

Fatty acid channeling into oxidation or storage modes depends on physiological conditions
and hormonal signaling. However, the directionality of this channeling may also depend on …

Lysine acetylation is involved in various biological processes and is considered a key
reversible post-translational modification in the regulation of gene expression, enzyme …

Because the signaling eicosanoids, epoxyeicosatrienoic acids (EETs) and HETEs, are
esterified to membrane phospholipids, we asked which long-chain acyl-CoA synthetase …

The increased prevalence of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia,
and fatty liver disease has provided increasingly negative connotations toward lipids …

Meeting the complex physiological demands of mammalian life requires strict control of the
metabolism of long-chain fatty acyl-CoAs because of the multiplicity of their cellular …

Altering the balance between energy intake and expenditure is a major strategy for treating
obesity. Nonetheless, despite the progression in antiobesity drugs on appetite suppression …