Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

The Krüppel-like factors (KLFs) family of proteins control several key biological processes
that include proliferation, differentiation, metabolism, apoptosis and inflammation …

The transcription factor KLF6 has an essential role in the development and metastasis of
multiple human cancers. Paradoxically, KLF6 expression was found to be attenuated in …

Abstract Background The 3'-untranslated region (3'-UTR) of mRNA contains regulatory
elements that are essential for the appropriate expression of many genes. These regulatory …

Data on intratumoral heterogeneity of small intestine neuroendocrine tumors (SI-NETs) and
related liver metastasis are limited. The aim of this study was to characterize genetic …

A Japanese study reported that up to 16% of breast cancer samples harbor a sporadic
mutation within the human Cav-1 gene, namely P132L. To date, however, no studies have …

Kruppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding
domain, and are involved in cell proliferation and differentiation control in normal as in …

Background Considering the increase in the proportion of lung adenocarcinoma (LUAD)
cases among all lung cancers and its considerable contribution to cancer‐related deaths …

Hepatocellular carcinoma (HCC) is a major public health concern because of the absence of
early diagnosis and effective treatments. Efficient diagnosis modalities and therapies to treat …