Muscarinic receptor signaling in the pathophysiology of asthma and COPD
Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for
asthma. Primarily used as bronchodilators, they reverse the action of vagally derived …
asthma. Primarily used as bronchodilators, they reverse the action of vagally derived …
Mechanisms of airway hyperresponsiveness
DW Cockcroft, BE Davis - Journal of allergy and clinical immunology, 2006 - Elsevier
Airway hyperresponsiveness (AHR) to direct (histamine and methacholine) and indirect
(exercise, cold air, hyperventilation, AMP) challenges is a universal and defining feature of …
(exercise, cold air, hyperventilation, AMP) challenges is a universal and defining feature of …
cAMP regulation of airway smooth muscle function
CK Billington, OO Ojo, RB Penn, S Ito - Pulmonary pharmacology & …, 2013 - Elsevier
Agonists activating β2-adrenoceptors (β2ARs) on airway smooth muscle (ASM) are the drug
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …
Asthma therapy and airway remodeling
T Mauad, EH Bel, PJ Sterk - Journal of allergy and clinical immunology, 2007 - Elsevier
Asthma is characterized by variable degrees of chronic inflammation and structural
alterations in the airways. The most prominent abnormalities include epithelial denudation …
alterations in the airways. The most prominent abnormalities include epithelial denudation …
IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation
MR Silver, A Margulis, N Wood, SJ Goldman… - Inflammation …, 2010 - Springer
Objective Mast cell and basophil activation contributes to inflammation, bronchoconstriction,
and airway hyperresponsiveness in asthma. Because IL-33 expression is inflammation …
and airway hyperresponsiveness in asthma. Because IL-33 expression is inflammation …
An official American Thoracic Society research statement: current challenges facing research and therapeutic advances in airway remodeling
YS Prakash, AJ Halayko, R Gosens… - American Journal of …, 2017 - atsjournals.org
Background: Airway remodeling (AR) is a prominent feature of asthma and other obstructive
lung diseases that is minimally affected by current treatments. The goals of this Official …
lung diseases that is minimally affected by current treatments. The goals of this Official …
Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype
BGJ Dekkers, D Schaafsma, T Tran… - American journal of …, 2009 - atsjournals.org
Airway smooth muscle (ASM) plays a key role in the development of airway
hyperresponsiveness and remodeling in asthma, which may involve maturation of ASM cells …
hyperresponsiveness and remodeling in asthma, which may involve maturation of ASM cells …
Phenotype modulation of airway smooth muscle in asthma
The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM
phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the …
phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the …
Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins
Airway smooth muscle (ASM) cells exhibit phenotype plasticity that is under control of
external stimuli such as growth factors and the extracellular matrix, and is regulated by a …
external stimuli such as growth factors and the extracellular matrix, and is regulated by a …
T Cells Localize with Proliferating Smooth Muscle α-Actin+ Cell Compartments in Asthma
D Ramos-Barbón, R Fraga-Iriso… - American journal of …, 2010 - atsjournals.org
Rationale: Airway remodeling in asthma comprises increased airway smooth muscle (ASM),
an alteration linked to airway hyperresponsiveness and disease severity. Experimental …
an alteration linked to airway hyperresponsiveness and disease severity. Experimental …