Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Sustainable and controlled delivery of drugs is at the centre of a huge amount of undertaken
researches. The ability of hydrogels, high water content materials, to achieve a local and …

Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

In solid cancers, activated fibroblasts acquire the capacity to provide fertile soil for tumor
progression. Specifically, cancer-associated fibroblasts (CAFs) establish a strong …

Angiogenesis is a complex morphogenetic process whereby endothelial cells from existing
vessels invade as multicellular sprouts to form new vessels. Here, we have engineered a …

Angiogenesis Page 1 CHAPTER 42 Angiogenesis JUDAH FOLKMAN I. Introduction
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels …

Angiogenesis is a key component of bone repair. New blood vessels bring oxygen and
nutrients to the highly metabolically active regenerating callus and serve as a route for …

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a
highly vascularised tissue reliant on the close spatial and temporal connection between …