Design of therapeutic biomaterials to control inflammation

Z Tu, Y Zhong, H Hu, D Shao, R Haag… - Nature Reviews …, 2022 - nature.com
Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Hydrogen sulfide: from a toxic molecule to a key molecule of cell life

A Aroca, C Gotor, DC Bassham, LC Romero - Antioxidants, 2020 - mdpi.com
Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles
published more recently showed the beneficial biochemical properties of its endogenous …

Development of triggerable, trackable, and targetable carbon monoxide releasing molecules

LS Lazarus, AD Benninghoff… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Carbon monoxide (CO) is a gaseous signaling molecule produced in humans
via the breakdown of heme in an O2-dependent reaction catalyzed by heme oxygenase …

Harnessing carbon monoxide-releasing platforms for cancer therapy

Y Zhou, W Yu, J Cao, H Gao - Biomaterials, 2020 - Elsevier
Carbon monoxide (CO) is a gaseous molecule that has drawn growing concerns for cancer
treatment, due to its multifaceted regulation of cellular function and the tumor …

Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response

Z Yuan, LK De La Cruz, X Yang, B Wang, Q Ma - Pharmacological Reviews, 2022 - Elsevier
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release

X Ji, Z Zhong - Journal of Controlled Release, 2022 - Elsevier
Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …

Role of carbon monoxide in host–gut microbiome communication

CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

Ligand-directed approach to activity-based sensing: developing palladacycle fluorescent probes that enable endogenous carbon monoxide detection

J Morstein, D Höfler, K Ueno, JW Jurss… - Journal of the …, 2020 - ACS Publications
Carbon monoxide (CO) is an emerging gasotransmitter and reactive carbon species with
broad anti-inflammatory, cytoprotective, and neurotransmitter functions along with …

[HTML][HTML] Click chemistry and drug delivery: A bird's-eye view

SM Kondengadan, S Bansal, C Yang, D Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …

Reactive oxygen species-activated metal-free carbon monoxide prodrugs for targeted cancer treatment

Z Li, Y Wang, M Liu, Y Pan, Z Ni, Q Min… - Journal of Medicinal …, 2023 - ACS Publications
Carbon monoxide has shown promise as a therapeutic agent against cancers. Reactive
oxygen species (ROS)-activated CO prodrugs are highly demanded for targeted cancer …