Cell Painting: a decade of discovery and innovation in cellular imaging

S Seal, MA Trapotsi, O Spjuth, S Singh… - Nature …, 2024 - nature.com
Modern quantitative image analysis techniques have enabled high-throughput, high-content
imaging experiments. Image-based profiling leverages the rich information in images to …

[HTML][HTML] A Decade in a Systematic Review: The Evolution and Impact of Cell Painting

S Seal, MA Trapotsi, O Spjuth, S Singh… - ArXiv, 2024 - ncbi.nlm.nih.gov
High-content image-based assays have fueled significant discoveries in the life sciences in
the past decade (2013–2023), including novel insights into disease etiology, mechanism of …

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysis

V Lejal, N Cerisier, D Rouquié… - Chemical Research in …, 2023 - ACS Publications
Drug-induced liver injury (DILI) is a significant concern in drug development, often leading to
drug withdrawal. Although many studies aim to identify biomarkers and gene/pathway …

[HTML][HTML] A method supporting fault-tolerant optical text recognition from video sequences recorded with handheld cameras

K Okarma, P Lech - Engineering Applications of Artificial Intelligence, 2023 - Elsevier
In the paper a method supporting the optical character recognition from video sequences
recorded with cameras without good stabilization is proposed. Due to the presence of …

Self-supervised representation learning for high-content screening

D Siegismund, M Wieser, S Heyse… - … on Medical Imaging …, 2022 - proceedings.mlr.press
Biopharma drug discovery requires a set of approaches to find, produce, and test the safety
of drugs for clinical application. A crucial part involves image-based screening of cell culture …

PCIM: Learning Pixel Attributions via Pixel-wise Channel Isolation Mixing in High Content Imaging

D Siegismund, M Wieser, S Heyse… - arXiv preprint arXiv …, 2024 - arxiv.org
Deep Neural Networks (DNNs) have shown remarkable success in various computer vision
tasks. However, their black-box nature often leads to difficulty in interpreting their decisions …

[HTML][HTML] Unleashing high content screening in hit detection–Benchmarking AI workflows including novelty detection

E Kupczyk, K Schorpp, K Hadian, S Lin, D Tziotis… - Computational and …, 2022 - Elsevier
Complex mixtures containing natural products are still an interesting source of novel drug
candidates. High content screening (HCS) is a popular tool to screen for such. In particular …

Using Cell Painting and Chemical Data for Small-molecule Bioactivity and Toxicity Prediction

S Seal - 2024 - repository.cam.ac.uk
High-content image-based assays have fueled significant discoveries in the life sciences in
the past decade, including novel insights into disease etiology, mechanism of action, new …

Statistical analyses of combinatorial effects in high-throughput biological data

MS Stadler - 2024 - edoc.ub.uni-muenchen.de
The advent of large-scale biological count data from high-throughput technologies has
made the development of suitable statistical techniques a cornerstone of modern …

Research on Key Information Extraction Algorithm in Image based on Visual Communication Technology

F Li, L Wang - … Conference on Evolutionary Algorithms and Soft …, 2023 - ieeexplore.ieee.org
With the development of image processing and artificial intelligence technology, image key
information extraction algorithm has become an indispensable tool and technology in many …