Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
Dedicated to the memory of Professors Henry G. Kunkel and Bruce Merrifield (Rockefeller
University, New York), who introduced us to the fascinating worlds of immunology and …
University, New York), who introduced us to the fascinating worlds of immunology and …
Intimate Molecular Interactions of P. falciparum Merozoite Proteins Involved in Invasion of Red Blood Cells and Their Implications for Vaccine Design
LE Rodriguez, H Curtidor, M Urquiza… - Chemical …, 2008 - ACS Publications
Intimate Molecular Interactions of P. falciparum Merozoite Proteins Involved in Invasion of Red
Blood Cells and Their Implications for Vaccine Design | Chemical Reviews ACS ACS …
Blood Cells and Their Implications for Vaccine Design | Chemical Reviews ACS ACS …
Structural characterisation of sporozoite components for a multistage, multi-epitope, anti-malarial vaccine
ME Patarroyo, G Cifuentes, R Rodríguez - The International Journal of …, 2008 - Elsevier
A totally effective anti-malarial vaccine must contain epitopes derived from multiple proteins
found in different stages of the particular parasite involved in invasion. It must therefore …
found in different stages of the particular parasite involved in invasion. It must therefore …
MHC allele-specific binding of a malaria peptide makes it become promiscuous on fitting a glycine residue into pocket 6
LE Vargas, CA Parra, LM Salazar, F Guzmán… - Biochemical and …, 2003 - Elsevier
Peptide 1585 (EVLYLKPLAGVYRSLKKQLE) has a highly conserved amino-acid sequence
located in the Plasmodium falciparum main merozoite surface protein (MSP-1) C-terminal …
located in the Plasmodium falciparum main merozoite surface protein (MSP-1) C-terminal …
Modified merozoite surface protein‐1 peptides with short alpha helical regions are associated with inducing protection against malaria
MH Torres, LM Salazar, M Vanegas… - European journal of …, 2003 - Wiley Online Library
The merozoite surface protein‐1 represents a prime candidate for development of a malaria
vaccine. Merozoite surface protein‐1 has been shown to demonstrate high‐activity peptide …
vaccine. Merozoite surface protein‐1 has been shown to demonstrate high‐activity peptide …
Immunogenicity and protectivity of Plasmodium falciparum EBA-175 peptide and its analog is associated with α-helical region shortening and displacement
A Bermúdez, G Cifuentes, F Guzmán, LM Salazar… - 2003 - degruyter.com
EBA-175 protein is used as a ligand in the binding of P. falciparum to red blood cells
(RBCs). Evidence shows that the conserved peptide 1779 from this protein (with high red …
(RBCs). Evidence shows that the conserved peptide 1779 from this protein (with high red …
Shortening and modifying the 1513 MSP-1 peptide's α-helical region induces protection against malaria
Immunogenic and protective peptide sequences are of prime importance in the search for an
anti-malarial vaccine. The MSP-1 conserved and semi-conserved sequences have been …
anti-malarial vaccine. The MSP-1 conserved and semi-conserved sequences have been …
Peptides Inducing Short-Lived Antibody Responses against Plasmodium falciparum Malaria Have Shorter Structures and Are Read in a Different MHC II Functional …
ME Patarroyo, MP Alba, LE Vargas, Y Silva… - Biochemistry, 2005 - ACS Publications
The search for a rational method of developing an antimalarial vaccine (malaria caused by
Plasmodium falciparum) consists of blocking receptor− ligand interaction. Conserved …
Plasmodium falciparum) consists of blocking receptor− ligand interaction. Conserved …
Modifying RESA protein peptide 6671 to fit into HLA-DRβ1* pockets induces protection against malaria
MP Alba, LM Salazar, LE Vargas, M Trujillo… - Biochemical and …, 2004 - Elsevier
6671 is a non-immunogenic, conserved high activity red blood cell binding peptide located
between residues 141 and 160 of the Plasmodium falciparum RESA protein. This peptide's …
between residues 141 and 160 of the Plasmodium falciparum RESA protein. This peptide's …
Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective
G Cifuentes, ME Patarroyo, M Urquiza… - Journal of medicinal …, 2003 - ACS Publications
The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2
peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective …
peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective …