Current algorithms for the clinical management of patients with squamous cell carcinoma of
the head and neck (HNSCC) are based on a stage-dependent strategy where all patients at …

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human
malignancy in the world, with high mortality and poor prognosis for patients. Among the risk …

Oral squamous cell carcinoma (OSCC) represents the sixth most common cancer,
accounting for 2–4% of all malignancies worldwide. The overall survival rate of less than …

CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich
matricellular protein is emerging as a key player in the development and progression of …

Around half of all patients with oral squamous cell carcinoma (OSCC) present with lymphatic
metastasis, a strong predictor of poor survival. Improving survival rates depends on …

Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins
that are important regulators and integrators of microenvironmental signals, contributing to …

Collagen linearization is a hallmark of aggressive tumors and a key pathogenic event that
promotes cancer cell invasion and metastasis. Cell‐generated mechanical tension has been …

Background Despite an early response to platinum-based chemotherapy in advanced stage
high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug …

Objectives In cT1‐2N0, oral squamous cell carcinoma (OSCC) occult metastases are
detected in 23%‐37% of cases. Sentinel lymph node biopsy (SLNB) was introduced in head …