[HTML][HTML] Coacervates as models of membraneless organelles

NA Yewdall, AAM André, T Lu, E Spruijt - Current Opinion in Colloid & …, 2021 - Elsevier
Coacervates are condensed liquid-like droplets, usually formed with oppositely charged
polymeric molecules. They have been studied extensively in colloid and interface science …

Membrane mimetic chemistry in artificial cells

JA Vance, NK Devaraj - Journal of the American Chemical Society, 2021 - ACS Publications
Lipid membranes in cells are fluid structures that undergo constant synthesis, remodeling,
fission, and fusion. The dynamic nature of lipid membranes enables their use as adaptive …

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

M Hallegger, AM Chakrabarti, FCY Lee, BL Lee… - Cell, 2021 - cell.com
Mutations causing amyotrophic lateral sclerosis (ALS) often affect the condensation
properties of RNA-binding proteins (RBPs). However, the role of RBP condensation in the …

Active coacervate droplets are protocells that grow and resist Ostwald ripening

KK Nakashima, MHI van Haren, AAM André… - Nature …, 2021 - nature.com
Active coacervate droplets are liquid condensates coupled to a chemical reaction that turns
over their components, keeping the droplets out of equilibrium. This turnover can be used to …

Multiphasic coacervates assembled by hydrogen bonding and hydrophobic interactions

X Liu, AH Mokarizadeh, A Narayanan… - Journal of the …, 2023 - ACS Publications
Coacervation has emerged as a prevalent mechanism to compartmentalize biomolecules in
living cells. Synthetic coacervates help in understanding the assembly process and mimic …

Connected peptide modules enable controlled co-existence of self-assembled fibers inside liquid condensates

A Jain, S Kassem, RS Fisher, B Wang… - Journal of the …, 2022 - ACS Publications
Supramolecular self-assembly of fibrous components and liquid–liquid phase separation
are at the extremes of the order-to-disorder spectrum. They collectively play key roles in …

Molecular crowding: the history and development of a scientific paradigm

C Alfano, Y Fichou, K Huber, M Weiss, E Spruijt… - Chemical …, 2024 - ACS Publications
It is now generally accepted that macromolecules do not act in isolation but “live” in a
crowded environment, that is, an environment populated by numerous different molecules …

Coacervates: Recent developments as nanostructure delivery platforms for therapeutic biomolecules

E Ban, A Kim - International Journal of Pharmaceutics, 2022 - Elsevier
Coacervation is a liquid–liquid phase separation that can occur in solutions of
macromolecules through self-assembly or electrostatic interactions. Recently, coacervates …

Complexity of spider dragline silk

AD Malay, HC Craig, J Chen, NA Oktaviani… - …, 2022 - ACS Publications
The tiny spider makes dragline silk fibers with unbeatable toughness, all under the most
innocuous conditions. Scientists have persistently tried to emulate its natural silk spinning …

Bio‐inspired functional coacervates: Special Issue: Emerging Investigators

S Chen, Q Guo, J Yu - Aggregate, 2022 - Wiley Online Library
Many functional coacervates have been identified in biological systems, which have
attracted widespread interest. Coacervation is a liquid–liquid phase separation (LLPS) …