It is textbook knowledge that carboxamides benefit from increased stabilisation of the
electrophilic carbonyl carbon when compared to other carbonyl and carboxyl derivatives …

Amides are a class of easily available compounds, and widely serve as versatile
intermediates in organic synthesis and medicinal chemistry. Amide-based transformations …

Multidrug resistance (MDR) is one of the main impediments in the treatment of cancers.
MDR cancer cells are resistant to multiple anticancer drugs. One of the major mechanisms of …

A strategy for the mild generation of synthetically valuable α-amino radicals from robust
tertiary amide building blocks has been developed. By combining Vaska's complex …

Fritillaria unibracteata is an endangered medicinal plant whose bulb has been used as a
Chinese herb to suppress cough, asthma and excessive phlegm for centuries. Steroidal …

Catalytic C–C bond forming methods for the one-pot transformation of amides into other
classes of compounds are highly demanding. In this report, we demonstrate the catalytic …

Fourteen quinolizidine derivatives, structurally related to the alkaloids lupinine and cytisine
and previously studied for other pharmacological purposes, were presently tested for …

The collective total syntheses of (±)‐hosieines A–C with a cage‐like tetracyclic framework
have been realized, which includes the first syntheses of hosieines B‐C. The key strategy of …

A continuously growing interest has emerged over the years pertinent to the sustainable
production of enantiomerically pure compounds for the food, agrochemical, fine chemicals …

Among c. 20 000 of known alkaloids isolated from natural sources and their numerous
derivatives, few belong to privileged chiral molecules that shaped the stereochemistry and …