Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …

Human lungs are organs with an intricate hierarchical structure and complex composition;
lungs also present heterogeneous mechanical properties that impose dynamic stress on …

Respiratory toxicology remains a major research area in the 21st century since current
scenario of airborne viral infection transmission and pollutant inhalation is expected to raise …

Preclinical human‐relevant modeling of organ‐specific vasculature offers a unique
opportunity to recreate pathophysiological intercellular, tissue‐tissue, and cell‐matrix …

The aim of this review is to provide a systematic design guideline to users, particularly
engineers interested in developing and deploying lung models, and biologists seeking to …

Asthma is a chronic lung disease involving airway inflammation and fibrosis. Fibroblasts are
the main effector cells important for lung tissue production which becomes abnormal in …

Exposure of lung tissues to cigarette smoke is a major cause of human disease and death
worldwide. Unfortunately, adequate model systems that can reliably recapitulate disease …

Background Respiratory diseases are the 2 nd leading cause of death globally. The current
treatments for chronic lung diseases are only supportive. Very few new classes of …

Lung disorders such as chronic obstructive pulmonary disease (COPD) and lower
respiratory tract infections (LRTIs) are leading causes of death in humans globally. Cigarette …

Highlights•Organotypic, organ-on-a-chip technologies with human cells improve human
relevance.•In silico modeling extrapolates in vitro testing results to in vivo health …