Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …

Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …

Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …

Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in
patients with breast cancer, but some patients may be more susceptible to ionizing radiation …

Deletions and duplications of chromosomal segments (copy number variants, CNVs) are a
major source of variation between individual humans and are an underlying factor in human …

Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

The ATM protein kinase is a primary activator of the cellular response to DNA double‐strand
breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in …

Structural changes to DNA severely affect its functions, such as replication and transcription,
and play a major role in age-related diseases and cancer. A complicated and entangled …

Breaks in both DNA strands are a particularly dangerous threat to genome stability. At a
DNA double-strand break (DSB), potentially lost sequence information cannot be recovered …