Congenital myasthenic syndromes (CMS) are a heterogeneous group of disorders
characterized by impaired neuromuscular signal transmission due to germline pathogenic …

The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

Muscle atrophy complicates many diseases as well as aging, and its presence predicts both
decreased quality of life and survival. Much work has been conducted to define the …

For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Sarcopenia and frailty are urgent socio-economic problems worldwide. Here we
demonstrate a functional connection between the lateral hypothalamus (LH) and skeletal …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Examining neural etiologic factors' role in the decline of neuromuscular function with aging
is essential to our understanding of the mechanisms underlying sarcopenia, the age …

The purpose was to determine the efficacy of deep dry needling (DDN) applied on an active
myofascial trigger point (MTrP) versus a latent-MTrP versus a non-MTrP location, on pain …

Recent studies of the CMS illustrate the increasing complexity of the genetics and
pathophysiological mechanisms involved. With therapy tailored for the underlying disease …