Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary
gland, uterus, brain and other target tissues for estrogen action, and this results in the …

Aromatase is the enzyme that catalyzes the conversion of androgens to estrogens. Initial
studies of its enzymatic activity and function took place in an environment focused on …

Because estrogen contributes to the promotion and progression of breast cancer, a greater
understanding of the role of estrogen in breast cancer has led to therapeutic strategies …

Recent clinical trials indicate that the third-generation aromatase inhibitors may be more
effective than tamoxifen as first line endocrine therapy in ER+ metastatic breast cancer in …

Aromatase inhibitors have recently been reported to be more effective than the antiestrogen
tamoxifen (Tam) in treating breast cancer. Here, we studied the mechanisms and signaling …

Letrozole is an oral reversible nonsteroidal aromatase inhibitor. Clinical tracer studies show
that it inhibits peripheral aromatase by over 98% and suppresses blood and urinary …

Objective We describe a phase II clinical trial of the combination of ribociclib and letrozole
for treatment of relapsed oestrogen receptor (ER)-positive ovarian cancer (OC) and …

Inhibitors of aromatase (estrogen synthetase) have been developed as treatment for
postmenopausal breast cancer. Both steroidal substrate analogs, type I inhibitors, which …

Ovariectomized mice bearing tumor xenografts grown from aromatase-transfected estrogen
receptor (ER)–positive human breast cancer cells (MCF-7Ca) were injected sc with 10 μg/d …

We have demonstrated that genistein (GEN) stimulates growth of estrogen-dependent
breast tumors in vivo. In this study, we evaluated whether dietary GEN can act in an additive …