The polarized distribution of functions in polarized cells requires the coordinated interaction
of three machineries that modify the basic mechanisms of intracellular protein trafficking and …

In the early days of epithelial cell biology, researchers working with kidney and/or intestinal
epithelial cell lines and with hepatocytes described the biosynthetic and recycling routes …

Lipid rafts are nanoscopic assemblies of sphingolipids, cholesterol, and specific membrane
proteins that contribute to lateral heterogeneity in eukaryotic membranes. Separation of …

Polarized epithelial cells have a distinctive apical–basal axis of polarity for vectorial
transport of ions and solutes across the epithelium. In contrast, migratory mesenchymal cells …

Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved post-translational
modification in eukaryotes. GPI is synthesized and transferred to proteins in the endoplasmic …

Sphingolipids, which comprise membrane systems together with other lipids, are ubiquitous
in cellular organisms. They show a high degree of diversity across plant species and vary in …

Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a class of
membrane proteins containing a soluble protein attached by a conserved glycolipid anchor …

Polarized distribution of plasma membrane transporters and receptors in epithelia is
essential for vectorial functions of epithelia. This polarity is maintained by sorting of …

In eukaryotes, many cell surface proteins are attached to the plasma membrane via a
glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) …

In eukaryotic cells, the trans-Golgi network serves as a sorting station for post-Golgi traffic. In
addition to coat-and adaptor-mediated mechanisms, studies in mammalian epithelial cells …