Objective Sensitization of mismatch repair (MMR)-deficient colorectal cancer (CRC) cells by
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …

Several reviews of inhibitors of topoisomerase II have been published, covering research
before 2018. Therefore, this review is focused primarily on more recent publications with …

Highlights•Nurturing NPs to create new therapeutics has been discussed.•Various
innovative strategies important for successful discovery of drugs, clinical candidates, and …

naphthoquinones hydroxyderivatives belong to an important class of natural products and
have been known as a favored scaffold in medicinal chemistry due to their multiple …

Cancer is a broad word for a set of diseases that can begin in virtually any organ or tissue of
the body and spread to other organs. In 2020, cancer was the largest cause of death …

An aryne annulation strategy for the synthesis of fused carbazoles is developed using
indolyl β-ketonitrile in a cascade manner. The reaction sequence involves aryne-mediated …

A divergent transformation of 2-amino-1, 4-quinones for the synthesis of pyrroquinone
derivatives and 2-halo-3-amino-1, 4-quinones was disclosed. The mechanistic study …

Endemic and pandemic viruses represent significant public health challenges, leading to
substantial morbidity and mortality over time. The COVID-19 pandemic has underscored the …

Multiple malignancies exhibit aberrant FASN expression, associated with enhanced de novo
lipogenesis to meet the metabolic demands of rapidly proliferating tumour cells …

DNA polymerase β (Polβ) is crucial for the base excision repair (BER) pathway of DNA
damage repair and is an attractive target for suppressing tumorigenesis as well as …