Background: The goal of comparative effectiveness research (CER) is to explain the
differential benefits and harms of alternate methods to prevent, diagnose, treat, and monitor …

Background: The US Office for Human Research Protections has proposed that end points
of randomized trials comparing the effectiveness of standard medical practices are risks of …

ALTHOUGH RANDOMIZED CONTROLLED trials have long been the gold standard of
clinical research, the needs of quality improvement (QI) research are somewhat different …

Background: The need for evidence about the effectiveness of therapeutics and other
medical practices has triggered new interest in methods for comparative effectiveness …

Comparative effectiveness research (CER) is thought to identify what works and does not
work in health care. We interpret CER as infusing evidence on product quality into markets …

Background/aims: In the context of research on medical practices, which includes
comparative effectiveness research and pragmatic clinical trials, empirical studies have …

Methods: 29 semi-structured telephone interviews were conducted with leaders within 25
health care institutions. Respondents were recruiting using purposive sampling, targeting …

Purpose: As multi-institutional research networks assume a central role in clinical research,
they must address the challenge of sustainability. Despite its importance, the concept of …

ABSTRACT PCORnet, the National Patient-Centered Clinical Research Network, seeks to
establish a robust national health data network for patient-centered comparative …

The article discusses the challenge of determining minimal risk in clinical trials for
comparative effectiveness. Mentioned are Surfactant, Positive Pressure, and Oxgyenation …