Alteplase is currently the only approved thrombolytic agent for treatment of acute ischaemic
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …

The treatment of acute ischemic stroke continues to advance. The mainstay of treatment
remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later …

Background The value of administering intravenous alteplase before endovascular
treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in …

Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …

Intravenous thrombolysis is the only approved systemic reperfusion treatment for patients
with acute ischaemic stroke. These European Stroke Organisation (ESO) guidelines provide …

Background The optimum systolic blood pressure after endovascular thrombectomy for
acute ischaemic stroke is uncertain. We aimed to compare the safety and efficacy of blood …

Importance Whether intravenous thrombolysis is needed in combination with mechanical
thrombectomy in patients with acute large vessel occlusion stroke is unclear. Objective To …

Background The benefit of combined treatment with intravenous thrombolysis before
endovascular thrombectomy in patients with acute ischaemic stroke caused by large vessel …

Summary Background Mobile stroke units (MSUs) equipped with a CT scanner reduce time
to thrombolytic treatment and improve patient outcomes. We tested the hypothesis that …

Importance For patients with large vessel occlusion strokes, it is unknown whether
endovascular treatment alone compared with intravenous thrombolysis plus endovascular …