In the mammalian brain, a family of sodium-dependent transporters maintains low
extracellular glutamate and shapes excitatory signaling. The bulk of this activity is mediated …

Background Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is
a recently identified cell adhesion molecule which is predominantly expressed by epithelial …

Transient multienzyme and/or multiprotein complexes (metabolons) direct substrates toward
specific pathways and can significantly influence the metabolism of glutamate and glutamine …

Objective Synonymous variants can lead to disease; nevertheless, the majority of
sequencing studies conducted in Alzheimer disease (AD) only assessed coding variation …

The sodium–iodide symporter (NIS) is an integral membrane protein that plays a crucial role
in iodide accumulation, especially in the thyroid. As for many other membrane proteins, its …

Na+/H+ exchanger regulatory factor (NHERF1) plays a critical role in the renal transport of
phosphate by binding to Na+-Pi cotransporter (NpT2a) in the proximal tubule. While the …

The Drosophila type I transmembrane protein Crumbs is an apical determinant required for
the maintenance of apico‐basal epithelial cell polarity. The level of Crumbs at the plasma …

Regulating γ-aminobutyric acid (GABA) uptake transport on the plasma membranes is
required for its efficient clearance from the brain interstitial fluid. The purpose of this study …

Glutamate transporters control the glutamate homeostasis in the central nervous system,
and, thus, are not only crucial for physiological excitatory synaptic signaling, but also for the …

One of the most important processes of the synaptic transmission is neurotransmitter uptake,
which is critical for the good performance of the nervous system by maintaining the …