Abstract Signal peptidase I (SPase I) is critical for the release of translocated preproteins
from the membrane as they are transported from a cytoplasmic site of synthesis to …

Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still
lacking a safe and effective vaccine for humans. Given this scenario, the search for a new …

Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …

Despite the development of a vaccine against cutaneous leishmaniasis in preclinical and
clinical studies, we still do not have a safe and effective vaccine for human use. Given this …

Serine proteases have significant functions over a broad range of relevant biological
processes to the Leishmania spp lifecycle. Data gathered here present an update on the …

Ticks and tick-borne pathogens affect health and welfare of companion animals worldwide,
and some human tick-borne diseases are associated with exposure to domestic animals …

Endoplasmic reticulum (ER) type I signal peptidases (ER SPases I) are vital proteases that
cleave signal peptides from secreted proteins. However, the specific function of ER SPase I …

Leishmaniases are neglected tropical diseases with great clinical and epidemiological
importance. The current chemotherapy available for the treatment of leishmaniasis presents …

In this study we investigated the peptidase activity in Leishmania (L.) amazonensis live
amastigote by confocal microscopy using peptidyl-MCA as substrates, the hydrolysis of …

Background Drug resistance is a common phenomenon frequently observed in countries
where leishmaniasis is endemic. Due to the production of the pteridine reductase enzyme …