Pyrazinamide (PZA) is an essential first-line tuberculosis drug for its unique mechanism of
action active against multidrug-resistant-TB (MDR-TB). Thus, the aim of updated meta …

Despite the use of ethnobotanical remedies to manage human immunodeficiency
virus/acquired immune deficiency syndrome (HIV/AIDS), there is paucity of empirical data on …

Background Tuberculosis (TB) remains a main global public health problem. However, a
systematic review of TB resistance epidemiology in Africa is wanting. Methods A …

Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance
tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather …

Introduction Susceptibility testing for pyrazinamide (PZA), a cornerstone anti-TB drug is not
commonly done in Uganda because it is expensive and characterized with technical …

Objectives Next-generation sequencing (NGS) can provide a comprehensive analysis of the
genetic alterations most commonly linked with pyrazinamide (PZA) resistance. However …

Objectives The burden of multidrug-resistant tuberculosis (MDR-TB) has been reported to be
increasing in Zambia. The reasons for the increase are still unclear. This study determined …

Without the proper information on pyrazinamide (PZA) susceptibility of Mycobacterium
tuberculosis (MTB), PZA is inappropriately recommended for the treatment of both …

Pyrazinamide (PZA) is an important anti-tuberculosis drug, which is active against semi-
dormant bacilli and used as a component of first-line drugs and drug-resistant tuberculosis …

Reliable drug susceptibility testing of pyrazinamide (PZA) is technically difficult, since PZA
activity is pH sensitive. The aim of this study was to evaluate a biphasic medium assay …